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Posted on Wed, Apr 20, 2011 : 10:30 a.m.

Vaccine for urinary tract infection is NanoBio's goal after getting University of Michigan license

By Nathan Bomey

Ann Arbor-based biotech firm NanoBio Corp. hopes to develop a vaccine for urinary tract infection after landing new intellectual property from the University of Michigan.

James Baker.jpg

James Baker, a U-M professor, is CEO of NanoBio.

File photo by Robert Ramey |'s Business Review

NanoBio, which is led by U-M professor James Baker, a global nanotechnology expert, has signed a deal to license an antigen that is showing early promise in preventing urinary tract infections after intranasal vaccinations.

NanoBio plans to take the antigen, which was developed by U-M scientists, and combine it with a nanoemulsion-based technology that NanoBio is already leveraging to create other new therapies.

Scientists expect development of a vaccine to take at least 10 years.

The deal tightens the already close relationship between NanoBio and U-M, which collaborate on several projects. Baker is also director of U-M’s Michigan Nanotechnology Institute for Medicine and Biological Studies.

The deal also comes as NanoBio is boosting its commitment to Ann Arbor. The company recently added four laboratories and office space at its headquarters on Green Road.

NanoBio is backed by deep-pocketed venture capital investors and a lucrative licensing deal from GlaxoSmithKline. The company employs more than 20 workers in Ann Arbor.

Contact's Nathan Bomey at (734) 623-2587 or You can also follow him on Twitter or subscribe to's newsletters.



Thu, Apr 21, 2011 : 3:53 p.m.

I love this! This is so exciting! I hope this will actually work!!! As a person with multiple UTI experience and a person whose had UTI's more than anything else, including the common cold, this is very exciting news! I hope this will work on other urological diseases like interstitial cystitis that is very similar to UTI's. As a woman, I am very thrilled about this new drug. It will be a lot better than taking tylenol, drinking cranberry juice like it's going out of business and hoping that the pain and the symptoms will stop. This will be so much better!


Thu, Apr 21, 2011 : 11:57 a.m.

Yes! HOORAY FOR VACCINATION! Folks, we NEED more vaccines! Just think how many people are dependent on the Big Pharma for their bread and butter. Would you have people like James Baker wind up on the street, adding to the panhandling problem, when he could be out strong-arming state legislators all over the country to mandate UTI vaccine for school attendance? The FDA can be enlisted to send their SWAT teams to health food stores and the few remaining "First Do No Harm" physicians' offices..... or wherever the true, but subversive information is disseminated that 100% of UTIs can be successfully prevented or treated with cranberries and/or d-Mannose. We can't have that!!! Such dangerous information might even lead to rumors that high dose IV vitamin C can knock out any infection - bacterial or viral - that any sane person knows is standard issue with a hospital visit these days. Vaccine are the "Miracle of Modern Medicine" that keep on giving to many bottom lines, as genetically susceptible folks can be counted on to require life-long medical services for the rest of their miserable lives. UP WITH "EVIDENCE BASED MEDICINE" and statistical manipulation!!!!! And, let's face it. Vaccines are the future of Big Pharma. Blockbuster drugs to replace those going rapidly off-patent need to be replaced with a reliable revenue stream. Vaccines ARE the answer. With the recent Supreme Court ruling in Bruesewitz v. Wyeth, manufacturers can charge ahead, unfettered by worries of any kind of legal liability for damage of any sort, no matter how foul the concoction. The PERFECT environment for moving Michigan forward! Sleep well, Mr. Baker!


Wed, Apr 20, 2011 : 7:32 p.m.

Perhaps some of you that are so quick to judge others should do a little urological research. In some individuals the lining of the bladder acts more like a keyhole for bacteria to lock onto, where in most individuals the lining of the bladder acts as a shield epels the bacteria and repels the bacteria. As you know, even with very good personal hygiene, it is quite easy for bacteria to find it's way into the bladder of a female, especially if she has previously given birth and has any problems with her pelvic floor. As a health care provider that gets frequent UTI's, but never an URI, I have been waiting for years for this research to advance to this point... Bravo for an immunization!!


Wed, Apr 20, 2011 : 6:05 p.m.

The real issue with developing a vaccine for something like a UTI is that for a bunch of people a UTI is totally preventable through proper hygiene. Not all of course, but a large portion of the women (most UTI's are in women) who get a UTI get them because of poor hygiene. Additionally, most UTI's are caused by the E. Coli bacteria. Obviously in the urinary tract E. Coli is bad, but in other places in the body (particularly the digestive tract), E. Coli is a vital and necessary bacteria. That's why taking a broad spectrum antibiotic often causes stomach problems. UTI's in elderly patients is a problem though and like someone else said a catheter can really increase the likelyhood of a UTI in elderly patients. Plus there are additional complications like dementia or Alzheimer's that can make detecting and treating a UTI difficult, which can lead to more serious bladder infections or ultimately a kidney infection which are obviously serious conditions that need the attention of a doctor. Anyway, I think most people who are careful and exercise good hygiene can probably avoid getting a UTI in the first place.


Wed, Apr 20, 2011 : 6:06 p.m.

You can read more at <a href="" rel='nofollow'></a>


Wed, Apr 20, 2011 : 4:24 p.m.

UTI can be a serious complication for persons who have other conditions or for the elderly and infirm. Further, it can be drug resistant and difficult to treat causing death or other serious illness--kidneys can especially be at risk. Finally, some people are susceptible to repeated UTI and develop scarring of the urethra or other complications. Vaccination seems to be a very promising treatment to those people: &quot;Vaccination Recent studies have shown that children and women who tend to get UTIs repeatedly may lack proteins called immunoglobulins, to fight infection. Early tests indicate that a vaccine helps patients build up their own natural infection-fighting powers. The dead bacteria in the vaccine do not spread like an infection; instead, they prompt the body to produce antibodies that can later fight against live organisms. Researchers are testing injected and oral vaccines to see which works best. Read more: UTI Treatment <a href="" rel='nofollow'></a>


Wed, Apr 20, 2011 : 4:15 p.m.

How is it that such a well-educated town has so many thoughtless and dim-witted comments on its news site? &quot;Each year, urinary catheters are inserted in more than 5 million patients in acute-care hospitals and extended-care facilities.&quot; Catheter-associated urinary tract infection is the most common type of infection acquired by patients while in hospitals and nursing homes, &gt;40% of all institutionally acquired infections. <a href="" rel='nofollow'></a> Gosh, you think maybe those 5 million people *a year* might be glad not to have to worry about urinary tract infections?


Wed, Apr 20, 2011 : 3:52 p.m.

Know how sometimes your eyelid will twitch and twitch and it drives you crazy... and you wonder if other people can see it? And then you have someone look at it and of course it stops twitching when they look at it? They should totally have a vaccine for that! Seriously... UTI??


Wed, Apr 20, 2011 : 3:17 p.m.

Vaccine for UTI? Give me a break! More people are getting sick due to vaccines rather than without it. Looks like our life is just dependent on vaccines and vitamin supplements as all food that is affordable is junk!